More Books:

Transcription Factors and Human Disease
Language: en
Pages: 368
Authors: Gregg L. Semenza
Categories: Health & Fitness
Type: BOOK - Published: 1998 - Publisher: Oxford Monographs on Medical G

Several general principles have emerged from the study of human transcription factors. First, germline mutations in genes encoding transcription factors result in malformation syndromes in which the development of multiple body structures is affected. Second, somatic mutations involving many of the same genes contribute to tumorigenesis. Third, transcriptional regulatory mechanisms
Eukaryotic Transcription Factors
Language: en
Pages: 488
Authors: David Latchman, David S. Latchman
Categories: Science
Type: BOOK - Published: 2010-07-28 - Publisher: Academic Press

Transcription, or the process by which DNA produces RNA, is a central aspect of gene expression. Transcription factors regulate transcription during development and in disease states. As such, it is critical for researchers to gain a good understanding of the relationship between the structure of various families of transcription factors
Gene Transcription
Language: en
Pages: 288
Authors: R. J. White
Categories: Science
Type: BOOK - Published: 2009-04-01 - Publisher: John Wiley & Sons

Transcription is the focus of much cutting-edge research, as befitsits essential place in biology. The established link betweendefects in gene transcription and many human disorders has fuelledconsiderable activity in the biomedical arena, particularly cancerresearch. This concentration of attention has uncovered a myriad offactors involved in transcription and the literature is
Transcription Factors
Language: en
Pages: 426
Authors: Paul J. Higgins
Categories: Science
Type: BOOK - Published: 2016-08-23 - Publisher: Humana

In the last few years, significant breakthroughs in transcription research expanded our appreciation for the complexity of molecular controls on gene expression in mammalian cells. In Transcription Factors: Methods and Protocols, experts in the field describe state-of-the-art approaches that investigators can use to probe critical mechanisms underlying transcription factor nuclear-cytoplasmic
Enhancers and Super-enhancers in Human Disease and Therapy
Language: en
Pages: 241
Authors: Heather Ashley Hoke, Massachusetts Institute of Technology. Department of Biology
Categories: Science
Type: BOOK - Published: 2014 - Publisher:

The human body is made up of a diverse array of cell types, each with specialized properties and functions that support the organism as a whole. Despite this variability, with few exceptions, these cells contain the same genetic information. The incredible diversity in cellular function arises from differences in gene